How much weight loss is actually significant?
Around 5% of your body weight over six months, without trying — roughly 4kg if you were 80kg, or 3kg if you were 60kg. Faster than that, or accompanied by any other symptom, and it should not wait. The key word throughout is unintentional: weight loss you worked for is not this symptom.
I'm actually pleased about it. Is that so bad?
It is completely understandable — and it is also the single commonest reason people wait too long. Weight that comes off without any change in what you eat or do has a cause, and the cause needs identifying whether or not the result is welcome. Plenty of the causes are eminently treatable; the point of checking is to find out which.
Could it just be stress or low mood?
Yes, and often it is. Depression, anxiety, bereavement and prolonged stress all genuinely reduce appetite and cause real weight loss. That is not a lesser explanation or a dismissal — it is a diagnosis in its own right that deserves treatment. But it is usually reached after the physical causes have been excluded, not instead of excluding them.
Does this mean cancer?
Usually not. Most unexplained weight loss turns out to have another cause — an overactive thyroid, undiagnosed diabetes, coeliac disease, inflammatory bowel disease, depression, or a medication effect. Cancer is one possibility among several, and it is the one that most rewards being found early, which is why the symptom is taken seriously rather than because it is the likeliest answer.
What are the most treatable causes?
Three worth knowing, because each is diagnosed with an ordinary blood test and each is entirely manageable:
- An overactive thyroid — weight loss with a racing heart, tremor, heat intolerance and anxiety
- Type 1 or newly diagnosed type 2 diabetes — weight loss with thirst and constant urination
- Coeliac disease — weight loss with bloating, loose stools and tiredness
I'm eating normally and still losing weight.
That is the pattern that most demands explanation. Weight loss despite a normal or increased appetite points towards the body either burning fuel too fast (an overactive thyroid), losing it in the urine (diabetes), or failing to absorb it (coeliac disease, pancreatic problems, inflammatory bowel disease). Say so explicitly when you are seen — it narrows things considerably.
I'm older, and I've heard this is normal with age.
It is not. Muscle mass does decline gradually with age, but frank unintentional weight loss in an older person is a genuine warning sign — for cancer, for thyroid disease, for depression, for difficulty with dentures or swallowing, and for simply not managing to shop and cook. It is one of the symptoms most often wrongly attributed to age and most worth investigating.
What tests would you arrange?
Typically full blood count, inflammatory markers, thyroid function, HbA1c, kidney and liver function, coeliac screening, and ferritin. That panel identifies the majority of causes. Where it is normal and the weight loss is real and significant, the next step is imaging and specialist referral — which we can arrange.