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Clopidogrel

Clopidogrel

An antiplatelet, not a blood thinner — and after a recent stent, stopping it can be dangerous.

Heart & Circulation

Plavix, antiplatelet, blood thinner

Explained by a GMC-registered GP, not a leaflet

Honest about what we can and cannot prescribe remotely

Side effects given the same weight as benefits

Your NHS records in the room, with your consent

Clinically reviewed by Dr Mohammad Khan · Last reviewed

August 30, 2026

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A 20-minute appointment with a GMC-registered GP for £40. Same-day appointments are usually available, 6am to 10pm, seven days a week.

Private GP care led personally by Dr Mohammad Zubair Khan, GMC 7563469.

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Same-Day Appointments
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Same-Day Appointments
Sick Notes
Private Prescriptions
Blood Tests
Menopause & HRT
Weight Management
Mental Health
Specialist Referrals

What it is

Clopidogrel is an antiplatelet. It stops platelets clumping together, which is the first step in forming a clot inside an artery.

Antiplatelets and anticoagulants are not the same thing, and the distinction is genuinely important:

  • Antiplatelets (clopidogrel, aspirin) act on platelets, and are used for clots in arteries — heart attacks, strokes, stents
  • Anticoagulants (apixaban, warfarin) act on clotting proteins, and are used for clots in veins and in atrial fibrillation

Both are called "blood thinners", which is why they get confused.

What it is used for

  • After a stroke or TIA — now first-line long-term in UK guidance, ahead of aspirin
  • After a heart attack or coronary stent, usually with aspirin for a defined period
  • Peripheral arterial disease
  • Where aspirin cannot be tolerated

How to take it

  • 75mg once daily, with or without food
  • Take it at the same time each day
  • A loading dose of 300 or 600mg is sometimes given at the start in hospital

Before any procedure

Tell every clinician, dentist and surgeon that you take clopidogrel, well in advance. Some procedures need it paused; many do not. Never pause it on your own judgment — particularly within the first year after a stent.

Need this reviewed or prescribed?

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Side effects

Common

  • Bruising more easily, and bleeding for longer from cuts
  • Nosebleeds
  • Indigestion, abdominal pain
  • Diarrhoea

Serious — seek help

  • Black tarry stools, or vomiting blood or material like coffee grounds — gastrointestinal bleeding. Emergency
  • Blood in the urine
  • Any head injury, even without symptoms — bleeding inside the skull can be delayed
  • Unexplained heavy or prolonged bleeding

Not suitable if

  • You have active bleeding, such as a bleeding ulcer
  • You have severe liver disease
  • You have had a bleed into the brain

Caution applies with a history of ulcers, and a proton pump inhibitor is often prescribed alongside for stomach protection.

Note that omeprazole and esomeprazole reduce clopidogrel's effect, so lansoprazole or pantoprazole is preferred for that purpose.

Interactions and monitoring

  • Omeprazole and esomeprazole — block the enzyme that activates clopidogrel, reducing its effect. Use lansoprazole or pantoprazole instead
  • NSAIDs including ibuprofen — substantially increased bleeding risk
  • Anticoagulants — the combination is sometimes deliberate and always high risk
  • SSRIs such as sertraline — added bleeding risk

No routine blood monitoring is needed. A full blood count may be checked where there is bleeding or anaemia.

Can we prescribe this?

Yes, to continue established treatment where the indication is documented and unchanged.

We will not start clopidogrel remotely, and we will not stop it. Starting it follows a specific diagnosis — stroke, TIA, peripheral arterial disease or a stent — made after assessment we cannot do by video.

Stopping it is the more dangerous of the two. After a recent coronary stent, stopping antiplatelet treatment early substantially raises the risk of the stent clotting off, which causes a heart attack. That decision belongs to the cardiology team, not to a remote consultation.

Cost and supply

Clopidogrel is an inexpensive generic and a month's supply typically costs less than the England NHS prescription charge on a private prescription.

Anyone taking it should carry a card or note saying so, which matters in an emergency.

Stopping or switching

Do not stop it without advice

This is the most important point on this page. After a recent stent, stopping antiplatelet treatment early can cause the stent to clot off — a potentially fatal heart attack.

Any decision to pause it for surgery or dental work is made by the team who put the stent in, or by your cardiologist.

Alternatives

  • Aspirin — cheaper, still used, though clopidogrel is now preferred after stroke
  • Ticagrelor or prasugrel — more potent, used after heart attacks for a defined period
  • Dipyridamole, occasionally added

If it causes indigestion

Do not stop it — ask about stomach protection. Lansoprazole or pantoprazole can be added safely; omeprazole should be avoided because it reduces the effect.

Common questions

Is this a blood thinner?

It is an antiplatelet, which is a different kind of blood thinner from an anticoagulant like apixaban. The distinction matters when other clinicians ask what you take — name the drug rather than the category.

Can I take ibuprofen?

Best avoided — it adds substantially to bleeding risk. Paracetamol is the safer choice, and topical anti-inflammatory gels are a reasonable middle ground.

I banged my head but feel fine.

Get assessed anyway. On an antiplatelet, bleeding inside the skull can develop hours later with no early symptoms.

Can I have dental treatment?

Usually yes, without stopping it. Tell your dentist in advance so they can plan.

Why was I told not to take omeprazole?

Because it blocks the enzyme that activates clopidogrel, making it less effective. Lansoprazole and pantoprazole do not have this problem.

Dr Mohammad Zubair Khan, GMC-registered private GP and founder of Cheshire Clinics

Clinically reviewed by Dr Mohammad Zubair Khan, GMC 7563469

Last reviewed

August 30, 2026

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What happens when you book

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Where testing will actually answer the question, we arrange it — blood tests and health screening through our laboratory partner, or a referral for ultrasound, X-ray, CT or MRI through private imaging providers. We will also tell you when a scan is not the right next step.
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Your GP talks you through what the results mean and agrees the next step with you. Every consultation ends with your treatment plan in writing, and any prescription goes to your own pharmacy.
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How we compare

Time to be seen

Appointment length

Your NHS record in the room

Written treatment plan

Told when a test isn’t needed

Cost

Varies by practice

Typically 10 minutes

Yes, your full record

Not routinely

Usually

Free

Same day

Often 10 to 15 minutes

Usually not

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Varies by provider

Often a subscription

Questions about our service

How quickly can I be seen?

Same-day access is usually available, from 6am to 10pm, seven days a week. You choose a time that suits you rather than waiting on hold at 8am.

Will I see the same doctor each time?

Yes. Care is led personally by Dr Mohammad Khan, so you are not passed between clinicians. Continuity is the point of a small practice: someone who knows your history and is listening attentively rather than working through a checklist.

Can you see my NHS records?

Yes, with your consent. We can access your Summary Care Record during the consultation, so your current medications, allergies and significant history are in the room. That means fewer questions you have already answered elsewhere, and safer prescribing.

Are you trying to replace my NHS GP?

No. We are not here to replace GPs, only to support them. Your NHS practice remains responsible for your ongoing care, and with your consent we write to them after the consultation. We are useful when you need to be seen sooner, or want more time than a standard appointment allows.

What is included in the appointment?

Twenty unhurried minutes and a comprehensive assessment. A written treatment plan is included, along with any prescription, sick note or referral letter arising from the consultation, at no extra charge.

How much does it cost?

£40 for 20 minutes, self-pay. Membership is optional and never required. Priced for fairness, because we are not here to charge extortionate amounts for access to a doctor.

What does “treatable online” actually mean?

It means the diagnosis can usually be made from your history and photographs, and that treatment can be arranged safely without examining you. Where a condition is not marked treatable online, it is because examination is the diagnosis — listening to a chest, feeling an abdomen, examining an ear or a joint — or because a procedure or device is needed.

Can you prescribe antibiotics?

Yes, where there is a genuine bacterial infection — cellulitis, impetigo, bacterial urine infections, confirmed strep throat. We will also frequently tell you that you do not need one. Most sore throats, coughs, colds and earaches are viral, and an antibiotic gives you the side effects with none of the benefit.

What if the GP cannot help with what I need?

If your problem turns out to be genuinely outside what we can do remotely, the doctor will tell you straight away, point you to the right service, and refund your fee in full. We would rather do that than fill twenty minutes to justify the charge.

What should I do in an emergency?

Call 999 or go to A&E — do not book an online appointment and do not wait for a reply to an email. For urgent problems that are not emergencies, NHS 111 is available 24 hours a day, online or by phone, and can direct you to the right service.

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