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Testosterone Replacement Therapy (TRT)

Testosterone Replacement Therapy (TRT)

Proper assessment for testosterone deficiency, with confirmatory morning bloods before any treatment decision.

£40 consultation, plus diagnostic bloods

Men's Health

Assessed and prescribed by a GMC-registered GP

Prescriptions sent electronically to a pharmacy

Monitoring and follow-up included where it is needed

Your NHS records in the room, with your consent

Clinically reviewed by Dr Mohammad Khan · Last reviewed

August 23, 2026

Book a consultation

A 20-minute appointment with a GMC-registered GP for £40. Same-day appointments are usually available, 6am to 10pm, seven days a week.

Private GP care led personally by Dr Mohammad Zubair Khan, GMC 7563469.

Why patients choose Cheshire Clinics

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GMC-registered

Care led personally by Dr Khan

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RCGP-trained

Attentive, unhurried care that listens properly

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Same-Day Appointments
Sick Notes
Private Prescriptions
Blood Tests
Menopause & HRT
Weight Management
Mental Health
Specialist Referrals
Same-Day Appointments
Sick Notes
Private Prescriptions
Blood Tests
Menopause & HRT
Weight Management
Mental Health
Specialist Referrals

Overview

Testosterone replacement is a long-term commitment with real consequences, and it should only follow a proper diagnosis. That means confirmed low readings on two separate early-morning blood tests, alongside genuine symptoms — not a single borderline result.

We assess honestly, including telling you when your symptoms are more likely explained by something else. Fatigue and low mood have many causes, and low testosterone is far from the commonest.

What it is

Testosterone replacement restores levels to the normal range, usually by gel or injection. Testosterone is a Schedule 4 controlled drug in the UK and is prescribed accordingly.

Who it's suitable for

You may be suitable if

  • You have genuine symptoms — fatigue, low libido, erectile difficulty, low mood, loss of muscle mass
  • Two separate early-morning samples confirm low testosterone
  • Other causes have been excluded
  • You are prepared to commit to long-term monitoring

You are not suitable if

  • Fertility is a current or near-future priority — treatment suppresses sperm production, often substantially
  • You have prostate or breast cancer, or an unexplained raised PSA
  • Your haematocrit is already above the safe threshold
  • You want treatment without monitoring

An honest word

Fatigue and low mood have many causes, and low testosterone is far from the commonest. A substantial proportion of men who come asking about TRT turn out to have normal levels and a different problem — often thyroid, sleep, iron or depression.

Finding that out is a good outcome, not a wasted appointment.

How treatment works

Initial consultation and diagnostic bloods, including total testosterone, LH, FSH, prolactin, SHBG, FBC and PSA where appropriate. A second confirmatory morning sample follows.

If deficiency is confirmed, treatment options are discussed and ongoing monitoring is arranged — this is not a treatment that can be started and left alone.

Ready to start treatment?

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What's included

Diagnosis — before any treatment

  • A full 20-minute consultation on symptoms and their likely causes
  • Diagnostic bloods: total testosterone, SHBG, free androgen index, LH, FSH, prolactin, FBC and PSA where age-appropriate
  • A second confirmatory morning sample, because a single low reading is not a diagnosis

If deficiency is confirmed

  • Discussion of preparation — gel or injection — and what each involves
  • A private prescription
  • A monitoring schedule, which is a condition of continued prescribing

Ongoing monitoring

Haematocrit, PSA, testosterone levels and symptoms, at defined intervals. This is not optional — testosterone thickens the blood, and unmonitored treatment is genuinely dangerous.

Safety and side effects

Testosterone raises red blood cell count, which requires regular monitoring as it can thicken the blood. Other effects include acne, oily skin, fluid retention, breast tenderness and worsening of sleep apnoea.

Treatment suppresses natural testosterone production and reduces fertility, often significantly. This matters if you may want children, and is discussed before any decision.

Not suitable if

Not suitable with prostate or breast cancer, an unexplained raised PSA, severe untreated sleep apnoea, a haematocrit above the safe threshold, or where fertility is a current priority.

Gels require care to avoid skin transfer to partners and children.

Monitoring and follow-up

Monitoring is a condition of prescribing, not an optional extra

Testosterone thickens the blood, and unmonitored treatment is genuinely dangerous. If you are not prepared to attend monitoring, we will not start you — and that is said at the outset rather than discovered later.

The schedule

  • 3 months — symptoms, testosterone level, and haematocrit
  • 6 months — the same, plus PSA where age-appropriate
  • 12 months, then annually — testosterone, haematocrit, PSA, lipids, liver function, blood pressure

Timing of the sample matters and depends on the preparation — mid-interval for injections, and a set number of hours after application for gels. A level taken at the wrong time is uninterpretable.

Haematocrit is the one that stops treatment

Testosterone raises red cell count, and a rising haematocrit is the commonest reason TRT has to be reduced or stopped. Thickened blood raises the risk of clot and stroke.

Above roughly 0.54 the dose is reduced or treatment paused, and venesection is sometimes needed. This is not a formality — it is why the blood tests exist.

What else is watched

  • PSA — testosterone does not cause prostate cancer, but it can accelerate an existing one. A significant rise needs urology assessment
  • Sleep apnoea, which testosterone can worsen. Snoring, witnessed pauses in breathing or daytime sleepiness need investigating rather than accepting
  • Blood pressure, acne, fluid retention and mood
  • Breast tenderness or enlargement, which is not uncommon

Fertility

TRT suppresses sperm production, often substantially, and sometimes it does not fully recover. This is the consequence men most regret not being told about.

If children are a possibility — even years away — raise it before starting, not after. Alternative approaches exist that raise testosterone without suppressing fertility, and sperm storage is worth considering.

Stopping

Natural production is suppressed while on treatment and takes months to recover, if it fully does. Symptoms usually return, often more sharply than before.

This is a long-term commitment. Anyone starting should understand that from the beginning rather than discovering it when they try to come off.

Alternatives

First — is it actually testosterone?

A substantial proportion of men who come asking about TRT have normal levels and a different, treatable problem. Finding that out is a good outcome, not a wasted appointment.

The usual candidates:

  • Sleep apnoea — very common, badly under-diagnosed, causes exactly this picture, and lowers testosterone in its own right. Treating it often raises levels without any hormone at all
  • Depression and burnout, which produce fatigue, low libido and low mood indistinguishably
  • Thyroid disease and iron deficiency
  • Alcohol, poor sleep and chronic stress, all of which lower testosterone directly
  • Medication — opioids in particular suppress testosterone substantially, as do some antidepressants and antipsychotics

Weight is the biggest reversible cause

Obesity lowers testosterone through conversion to oestrogen in fat tissue, and weight loss raises it measurably. For men whose levels are borderline, this often resolves the problem without lifelong treatment — see weight management.

If fertility matters

TRT is the wrong treatment. Where testosterone is low because of a pituitary cause, hCG or clomifene can raise levels while preserving sperm production — usually specialist territory, and worth a referral rather than accepting TRT by default.

Treating the symptom instead

PDE5 inhibitors for erectile difficulty work regardless of testosterone level and are far simpler than lifelong hormone treatment.

What does not work

Over-the-counter "testosterone boosters" have no good evidence, are unregulated, and occasionally contain undeclared pharmaceutical ingredients. Save your money.

Anabolic steroids bought online are a different matter entirely — doses many times therapeutic, no monitoring, and real cardiac, fertility and mental health consequences. If you are using them, tell us. We will not judge and we can help you come off safely, which is genuinely difficult to do alone.

Costs explained

What you pay us

  • £40 for the initial consultation, charged whether or not treatment follows — and it frequently does not, because the assessment often finds a different explanation
  • Diagnostic bloods, quoted before they are arranged. Two separate early-morning samples are needed, because a single low reading is not a diagnosis
  • £40 for each monitoring appointment — at 3, 6 and 12 months, then annually
  • Monitoring bloods at each of those points

What you pay the pharmacy

Testosterone gels and injections, paid to your pharmacy. Injections are generally cheaper per month than gels. We do not dispense and earn nothing from what is prescribed.

Add it up before you start

This is the honest part. TRT is a lifelong commitment, and the cost is not the first prescription — it is medication plus two to four monitoring appointments and blood tests every year, indefinitely.

Work out the annual figure before starting, because stopping after a year leaves you worse off than before: natural production is suppressed and takes months to recover, if it fully does.

Check the NHS route first

Genuine testosterone deficiency is treated on the NHS, and if two morning samples confirm it, your own GP can prescribe and monitor — free in Scotland, Wales and Northern Ireland, and at prescription charge in England.

We will say so if that is the better route for you.

What to watch for in this market — said plainly

Private testosterone clinics are a commercially aggressive corner of medicine, and the incentives are not always aligned with you. Be cautious of any service that:

  • Diagnoses from a single blood test, or from an afternoon sample
  • Treats a borderline result as deficiency without excluding anything else
  • Bundles medication and monitoring into a monthly subscription, which creates a financial interest in keeping you on treatment
  • Sells supplements alongside
  • Does not discuss fertility before starting

We charge for consultations and tests, and for nothing else. There is no subscription, and no fee that depends on you being prescribed anything.

Common questions

Can you diagnose it from one blood test?

No, and anyone who does is not diagnosing properly. Diagnosis needs two separate early-morning samples — testosterone follows a daily rhythm and is highest in the morning — alongside genuine symptoms, and with other causes excluded.

An afternoon sample can look low in a man with entirely normal levels.

My level is low-normal but I have all the symptoms. Will you treat me?

Not on that basis alone, and this is where we will differ from some private clinics.

A borderline result with symptoms is far more often explained by sleep apnoea, depression, thyroid disease, iron deficiency, alcohol, poor sleep or weight than by testosterone deficiency — and starting lifelong hormone treatment for a problem you do not have means the real cause goes untreated.

We will look for the real cause. That is what the appointment is for.

Will TRT affect my fertility?

Yes, substantially, and this is the thing men most often say they were not told. It suppresses sperm production, sometimes to zero, and recovery after stopping is not guaranteed.

If children are a possibility, even years away, say so before starting. Alternatives exist that raise testosterone without suppressing fertility, and sperm storage is worth considering.

Can I stop once I start?

You can, but understand what that means. Natural production is suppressed while on treatment and takes months to recover — sometimes not fully. Symptoms usually return, often more sharply than before.

Treat this as a long-term commitment from the beginning.

Why so much monitoring?

Mainly haematocrit. Testosterone raises red cell count, thickened blood raises clot and stroke risk, and a rising haematocrit is the commonest reason treatment has to be reduced or stopped.

Also PSA, blood pressure, and sleep apnoea, which testosterone can worsen. Monitoring is a condition of continued prescribing here — no monitoring, no prescription.

Does it cause prostate cancer?

The evidence does not show that testosterone causes prostate cancer. But it can accelerate an existing one, which is why PSA is checked before starting and monitored afterwards, and why an unexplained raised PSA rules it out until investigated.

Gel or injection?

Injections — less frequent, cheaper, and levels fluctuate more between doses.

Gels — steadier levels and daily application, but transfer to partners and children through skin contact is a real risk. Cover the area, wash your hands, and do not let a child rest against it.

Will it fix my tiredness?

If testosterone deficiency is genuinely the cause, often yes. If it is not, no — and that is the far commoner situation.

Fatigue has many causes and low testosterone is not among the commonest. Treating the wrong one costs money, carries risk, and leaves the real problem in place.

What about testosterone boosters from the gym or online?

No good evidence, unregulated, and occasionally containing undeclared pharmaceutical ingredients. Save your money.

Anabolic steroids are a separate and more serious matter — doses many times therapeutic, no monitoring, and real cardiac, fertility and mental health consequences. If you are using them, tell us. We are not here to judge, and coming off safely is difficult without help.

Is testosterone a controlled drug?

Yes — Schedule 4 in the UK, and prescribed accordingly, with the record-keeping and monitoring that implies.

How is this different from a testosterone clinic?

Chiefly in what we are prepared to say no to, and in how we are paid.

We charge for consultations and tests, and nothing else — no subscription, no medication margin, no supplements. Which means there is no financial reason for us to find you deficient.

Dr Mohammad Zubair Khan, GMC-registered private GP and founder of Cheshire Clinics

Clinically reviewed by Dr Mohammad Zubair Khan, GMC 7563469

Last reviewed

August 23, 2026

How it works

What happens when you book

£40 for a 20-minute appointment with a GMC-registered GP, 6am to 10pm, seven days a week. Membership is optional and never required.
Cheshire Clinics online GP appointment booking confirmation on mobile
01

Book your appointment

Pick a time that suits you — 6am to 10pm, seven days a week, including weekends and bank holidays. £40 for 20 minutes, self-pay, with no insurance to arrange.
5–10 minutes
Online video consultation with a GMC-registered private GP
02

Meet your GP

A 20-minute video or phone consultation with a GMC-registered GP — long enough for a proper conversation about your symptoms, your history and what matters to you.
20 minutes
Diagnostic testing plan including blood test panel, ECG and urine screening
03

Tests and referrals, if you need them

Where testing will actually answer the question, we arrange it — blood tests and health screening through our laboratory partner, or a referral for ultrasound, X-ray, CT or MRI through private imaging providers. We will also tell you when a scan is not the right next step.
1–7 days
Personalised results and treatment plan from a private GP consultation
04

Results and next steps

Your GP talks you through what the results mean and agrees the next step with you. Every consultation ends with your treatment plan in writing, and any prescription goes to your own pharmacy.
20 minutes
GP follow-up reminder for ongoing care and progress monitoring
05

Ongoing care and follow-up

Follow-up appointments, progress monitoring and ongoing advice — including saying plainly when something needs in-person or NHS care instead.

Ongoing

How we compare

Time to be seen

Appointment length

Your NHS record in the room

Written treatment plan

Told when a test isn’t needed

Cost

Varies by practice

Typically 10 minutes

Yes, your full record

Not routinely

Usually

Free

Same day

Often 10 to 15 minutes

Usually not

Sometimes charged

Varies by provider

Often a subscription

Questions about our service

How quickly can I be seen?

Same-day access is usually available, from 6am to 10pm, seven days a week. You choose a time that suits you rather than waiting on hold at 8am.

Will I see the same doctor each time?

Yes. Care is led personally by Dr Mohammad Khan, so you are not passed between clinicians. Continuity is the point of a small practice: someone who knows your history and is listening attentively rather than working through a checklist.

Can you see my NHS records?

Yes, with your consent. We can access your Summary Care Record during the consultation, so your current medications, allergies and significant history are in the room. That means fewer questions you have already answered elsewhere, and safer prescribing.

Are you trying to replace my NHS GP?

No. We are not here to replace GPs, only to support them. Your NHS practice remains responsible for your ongoing care, and with your consent we write to them after the consultation. We are useful when you need to be seen sooner, or want more time than a standard appointment allows.

What is included in the appointment?

Twenty unhurried minutes and a comprehensive assessment. A written treatment plan is included, along with any prescription, sick note or referral letter arising from the consultation, at no extra charge.

How much does it cost?

£40 for 20 minutes, self-pay. Membership is optional and never required. Priced for fairness, because we are not here to charge extortionate amounts for access to a doctor.

What does “treatable online” actually mean?

It means the diagnosis can usually be made from your history and photographs, and that treatment can be arranged safely without examining you. Where a condition is not marked treatable online, it is because examination is the diagnosis — listening to a chest, feeling an abdomen, examining an ear or a joint — or because a procedure or device is needed.

Can you prescribe antibiotics?

Yes, where there is a genuine bacterial infection — cellulitis, impetigo, bacterial urine infections, confirmed strep throat. We will also frequently tell you that you do not need one. Most sore throats, coughs, colds and earaches are viral, and an antibiotic gives you the side effects with none of the benefit.

What if the GP cannot help with what I need?

If your problem turns out to be genuinely outside what we can do remotely, the doctor will tell you straight away, point you to the right service, and refund your fee in full. We would rather do that than fill twenty minutes to justify the charge.

What should I do in an emergency?

Call 999 or go to A&E — do not book an online appointment and do not wait for a reply to an email. For urgent problems that are not emergencies, NHS 111 is available 24 hours a day, online or by phone, and can direct you to the right service.

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