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Bisoprolol

Bisoprolol

The heart-selective beta blocker — and one of the few medicines where feeling worse at the start is expected.

Heart & Circulation

Cardicor, Congescor, beta blocker

Explained by a GMC-registered GP, not a leaflet

Honest about what we can and cannot prescribe remotely

Side effects given the same weight as benefits

Your NHS records in the room, with your consent

Clinically reviewed by Dr Mohammad Khan · Last reviewed

August 30, 2026

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Private Prescriptions
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Weight Management
Mental Health
Specialist Referrals

What it is

Bisoprolol is a cardioselective beta blocker. It blocks beta-1 receptors, which sit mainly on the heart, so it slows the heart rate and reduces the force of each beat.

Cardioselective matters practically: it acts far less on the beta-2 receptors in the airways than older beta blockers such as propranolol, which is why it can often be used cautiously in people with asthma or COPD where propranolol cannot.

In heart failure it does something counterintuitive — it makes people feel slightly worse for a few weeks and then measurably better, and it reduces mortality. Understanding that in advance is what stops people abandoning it in week two.

What it is used for

  • Atrial fibrillation — controlling the heart rate
  • Heart failure with reduced ejection fraction — where it improves survival
  • Angina
  • After a heart attack
  • High blood pressure, though no longer first-line for that alone

How to take it

  • Once daily, usually in the morning, with or without food
  • Started low and increased slowly, particularly in heart failure where doses are doubled no faster than every two weeks
  • Take it at the same time each day

What to expect early

Tiredness and a general flatness in the first two to four weeks is common and usually settles. In heart failure, mild worsening of breathlessness during up-titration is expected rather than a sign the drug is wrong.

Do not stop because of this. Report it instead — the pace of increase can be slowed.

Need this reviewed or prescribed?

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Side effects

Common

  • Tiredness, particularly early
  • Cold hands and feet
  • Dizziness, especially on standing
  • Slow pulse
  • Vivid dreams or disturbed sleep — less than with propranolol

Less common

  • Worsening wheeze in asthma
  • Erectile dysfunction
  • Masking of low blood sugar warning signs in diabetes

Not suitable if

  • You have a very slow heart rate or significant heart block
  • You have severe or unstable asthma — caution applies even with cardioselective agents
  • You have untreated decompensated heart failure
  • You have severe peripheral arterial disease
  • You have very low blood pressure

Diabetes is not a barrier, but bisoprolol blunts the adrenaline warning signs of hypoglycaemia — sweating and tremor — which is worth knowing if you take insulin or a sulfonylurea.

Interactions and monitoring

  • Verapamil and diltiazem — combined with a beta blocker this can slow the heart dangerously. Verapamil in particular should be avoided
  • Other rate-slowing medicines, including digoxin and amiodarone
  • NSAIDs — reduce the blood pressure benefit
  • Insulin and sulfonylureas — masked hypoglycaemia

Monitoring

Heart rate and blood pressure at every dose change, plus kidney function and electrolytes in heart failure. A resting pulse below about 50 warrants review.

Can we prescribe this?

Yes, to continue established treatment where the diagnosis is clear and things are stable.

We will not start bisoprolol for heart failure remotely. That requires an echocardiogram, careful up-titration and monitoring of kidney function and blood pressure at each step — it is specialist-initiated for good reason.

Nor will we manage new or uncontrolled atrial fibrillation at a distance. That needs an ECG, a stroke risk assessment and a decision about anticoagulation, which is the part that actually prevents strokes.

Cost and supply

Bisoprolol is a very cheap generic. A month's supply on a private prescription typically costs less than the England NHS prescription charge.

Available in several strengths, which matters because doses are titrated gradually.

Stopping or switching

Never stop abruptly

Stopping a beta blocker suddenly after regular use can cause rebound rapid heart rate and raised blood pressure, and in people with heart disease it can precipitate angina or a heart attack.

Reduction is gradual, typically halving the dose every few days to weeks under supervision.

If it is not tolerated

  • Tiredness — often settles by week four; a slower increase usually helps
  • Cold hands and feet — common and generally manageable
  • Wheeze — report promptly; the drug may need changing

Alternatives

  • Other beta blockers — carvedilol and nebivolol in heart failure, atenolol elsewhere
  • Diltiazem for rate control in atrial fibrillation where a beta blocker cannot be used — but not alongside one
  • Amlodipine, ramipril or an ARB where the indication is blood pressure

Common questions

Why do I feel worse since starting it?

Early tiredness is expected and usually settles within a month. In heart failure, a temporary dip is part of how the drug works — the benefit comes later and is substantial.

Can I take it with asthma?

Often yes, cautiously, because it is cardioselective — but not with severe or unstable asthma. Report any new wheeze.

My pulse is in the 50s. Is that a problem?

A slower pulse is the drug working. Below 50, or with dizziness, blackouts or breathlessness, seek review.

Can I drink alcohol?

Moderate alcohol is generally fine, though it adds to dizziness, especially early on.

Can I exercise?

Yes, and you should — but your maximum heart rate will be lower, so judge effort by how you feel rather than by a heart rate target.

Dr Mohammad Zubair Khan, GMC-registered private GP and founder of Cheshire Clinics

Clinically reviewed by Dr Mohammad Zubair Khan, GMC 7563469

Last reviewed

August 30, 2026

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