Apixaban

No INR tests and few food restrictions — but a short action, so missed doses matter more than they did with warfarin.

Heart & Circulation

Eliquis, DOAC, NOAC, blood thinner

Explained by a GMC-registered GP, not a leaflet

Honest about what we can and cannot prescribe remotely

Side effects given the same weight as benefits

Your NHS records in the room, with your consent

Clinically reviewed by Dr Mohammad Khan · Last reviewed

August 30, 2026

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A 20-minute appointment with a GMC-registered GP for £40. Same-day appointments are usually available, 6am to 10pm, seven days a week.

Private GP care led personally by Dr Mohammad Zubair Khan, GMC 7563469.

Why patients choose Cheshire Clinics

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GMC-registered

Care led personally by Dr Khan

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RCGP-trained

Attentive, unhurried care that listens properly

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Registered with the Care Quality Commission

Same-Day Appointments
Sick Notes
Private Prescriptions
Blood Tests
Menopause & HRT
Weight Management
Mental Health
Specialist Referrals
Same-Day Appointments
Sick Notes
Private Prescriptions
Blood Tests
Menopause & HRT
Weight Management
Mental Health
Specialist Referrals

What it is

Apixaban is a direct oral anticoagulant — a DOAC. It blocks factor Xa, one of the proteins in the clotting cascade, reducing the blood's ability to form clots.

It has largely replaced warfarin for most indications because it needs no routine INR blood tests, has far fewer food interactions, and works predictably at a fixed dose.

The trade-off is that it acts for a shorter time. Warfarin's effect persists for days, so a missed dose mattered little. Apixaban's effect fades within about 12 hours, so missing doses genuinely leaves you unprotected.

What it is used for

  • Atrial fibrillation — to prevent stroke. This is the commonest reason
  • Treating DVT and pulmonary embolism
  • Preventing recurrence of DVT and PE
  • Preventing clots after hip and knee replacement

In atrial fibrillation, anticoagulation is the part of treatment that prevents strokes. Rate control makes you feel better; anticoagulation is what protects you.

How to take it

  • Twice daily, roughly twelve hours apart, with or without food
  • Usually 5mg twice daily, reduced to 2.5mg twice daily where age, weight and kidney function meet certain criteria
  • Higher doses are used for the first week or so when treating a new clot

Missed doses

Take it as soon as you remember on the same day, then continue as normal. Never double up.

Taking it twice daily reliably is the whole point. A pill organiser, a phone alarm, or pairing it with breakfast and an evening routine all help — and this is one medicine where adherence genuinely determines whether it works.

Need this reviewed or prescribed?

Book a consultation

Side effects

Common

  • Bruising, and bleeding for longer from cuts
  • Nosebleeds
  • Heavier periods
  • Blood in the urine

Serious — seek help immediately

  • Black tarry stools, or vomiting blood or material like coffee grounds
  • Any head injury, however minor it feels — bleeding inside the skull can be delayed by hours and is the reason this matters
  • Sudden severe headache, weakness, confusion or vision change
  • Bleeding that will not stop
  • Unexplained severe bruising or swelling

Not suitable if

  • You have active clinically significant bleeding
  • You have severe liver disease with a coagulation problem
  • You have a mechanical heart valve — warfarin is required, as DOACs are inferior here
  • You have severe kidney impairment
  • You are pregnant or breastfeeding
  • You have moderate to severe mitral stenosis

Interactions and monitoring

  • NSAIDs including ibuprofen — substantially increased bleeding risk. Paracetamol is the safer painkiller
  • Antiplatelets — combined only where deliberately intended
  • Clarithromycin, ketoconazole and ritonavir — raise apixaban levels
  • Rifampicin, carbamazepine, phenytoin and St John's wort — lower levels and reduce protection
  • SSRIs — added bleeding risk

Monitoring

No INR testing is needed. But kidney function, full blood count and liver function should be checked at least annually, and more often where kidney function is borderline — because the dose depends on it.

Weight and age also affect dosing, so significant weight change is worth reporting.

Can we prescribe this?

Yes, to continue established treatment where the indication is documented, the dose is stable and recent kidney function is available.

We will not start anticoagulation remotely. Starting it requires a formal stroke risk assessment, a bleeding risk assessment, kidney function, weight, and a discussion of the trade-off between preventing strokes and causing bleeds. That is a face-to-face conversation.

Suspected DVT or pulmonary embolism is an emergency, not a prescription request. A swollen painful calf, or sudden breathlessness or chest pain, needs same-day assessment and scanning.

Cost and supply

Apixaban is now available as a generic and has become considerably cheaper, though it still costs more than warfarin.

Against that, warfarin requires regular INR blood tests, so the total cost and inconvenience often favours apixaban.

Carry an anticoagulant alert card at all times. Available free from pharmacies, and genuinely important in an emergency.

Stopping or switching

Do not stop without advice

Protection is lost within about 12 to 24 hours. In atrial fibrillation, stopping raises stroke risk immediately.

Pausing before surgery or dental work is planned in advance, based on the procedure's bleeding risk and your kidney function — typically 24 to 48 hours, and restarted promptly afterwards.

Reversal

A specific reversal agent exists for apixaban, held in hospitals for serious bleeding. Worth knowing, as the lack of a reversal agent was a common early objection to DOACs.

Alternatives

  • Rivaroxaban — once daily, which suits some people better; must be taken with food at treatment doses
  • Edoxaban — once daily
  • Warfarin — required for mechanical valves; needs INR monitoring

Common questions

What if I miss a dose?

Take it as soon as you remember that day, then carry on as normal. Never double up. Missing doses matters more than it did with warfarin, because the effect wears off within about half a day.

Do I still need blood tests?

Not INR tests — but yes, kidney function at least annually. The dose depends on it, and kidney function changes with age and illness.

Can I drink alcohol?

Moderate alcohol is generally acceptable. Heavy drinking increases bleeding risk and the risk of falls, which is the real hazard.

I hit my head but I feel fine.

Get assessed today. This is the single most important safety point — bleeding inside the skull on an anticoagulant can be silent for hours and then sudden.

Can I take ibuprofen?

Avoid it. Paracetamol is the safer choice; topical gels are a reasonable alternative for joint pain.

Do I need to avoid green vegetables?

No — that was warfarin. Apixaban has no vitamin K interaction, so eat normally.

Dr Mohammad Zubair Khan, GMC-registered private GP and founder of Cheshire Clinics

Clinically reviewed by Dr Mohammad Zubair Khan, GMC 7563469

Last reviewed

August 30, 2026

How it works

What happens when you book

£40 for a 20-minute appointment with a GMC-registered GP, 6am to 10pm, seven days a week. Membership is optional and never required.
Cheshire Clinics online GP appointment booking confirmation on mobile
01

Book your appointment

Pick a time that suits you — 6am to 10pm, seven days a week, including weekends and bank holidays. £40 for 20 minutes, self-pay, with no insurance to arrange.
5–10 minutes
Online video consultation with a GMC-registered private GP
02

Meet your GP

A 20-minute video or phone consultation with a GMC-registered GP — long enough for a proper conversation about your symptoms, your history and what matters to you.
20 minutes
Diagnostic testing plan including blood test panel, ECG and urine screening
03

Tests and referrals, if you need them

Where testing will actually answer the question, we arrange it — blood tests and health screening through our laboratory partner, or a referral for ultrasound, X-ray, CT or MRI through private imaging providers. We will also tell you when a scan is not the right next step.
1–7 days
Personalised results and treatment plan from a private GP consultation
04

Results and next steps

Your GP talks you through what the results mean and agrees the next step with you. Every consultation ends with your treatment plan in writing, and any prescription goes to your own pharmacy.
20 minutes
GP follow-up reminder for ongoing care and progress monitoring
05

Ongoing care and follow-up

Follow-up appointments, progress monitoring and ongoing advice — including saying plainly when something needs in-person or NHS care instead.

Ongoing

How we compare

Time to be seen

Appointment length

Your NHS record in the room

Written treatment plan

Told when a test isn’t needed

Cost

Varies by practice

Typically 10 minutes

Yes, your full record

Not routinely

Usually

Free

Same day

Often 10 to 15 minutes

Usually not

Sometimes charged

Varies by provider

Often a subscription

Questions about our service

How quickly can I be seen?

Same-day access is usually available, from 6am to 10pm, seven days a week. You choose a time that suits you rather than waiting on hold at 8am.

Will I see the same doctor each time?

Yes. Care is led personally by Dr Mohammad Khan, so you are not passed between clinicians. Continuity is the point of a small practice: someone who knows your history and is listening attentively rather than working through a checklist.

Can you see my NHS records?

Yes, with your consent. We can access your Summary Care Record during the consultation, so your current medications, allergies and significant history are in the room. That means fewer questions you have already answered elsewhere, and safer prescribing.

Are you trying to replace my NHS GP?

No. We are not here to replace GPs, only to support them. Your NHS practice remains responsible for your ongoing care, and with your consent we write to them after the consultation. We are useful when you need to be seen sooner, or want more time than a standard appointment allows.

What is included in the appointment?

Twenty unhurried minutes and a comprehensive assessment. A written treatment plan is included, along with any prescription, sick note or referral letter arising from the consultation, at no extra charge.

How much does it cost?

£40 for 20 minutes, self-pay. Membership is optional and never required. Priced for fairness, because we are not here to charge extortionate amounts for access to a doctor.

What does “treatable online” actually mean?

It means the diagnosis can usually be made from your history and photographs, and that treatment can be arranged safely without examining you. Where a condition is not marked treatable online, it is because examination is the diagnosis — listening to a chest, feeling an abdomen, examining an ear or a joint — or because a procedure or device is needed.

Can you prescribe antibiotics?

Yes, where there is a genuine bacterial infection — cellulitis, impetigo, bacterial urine infections, confirmed strep throat. We will also frequently tell you that you do not need one. Most sore throats, coughs, colds and earaches are viral, and an antibiotic gives you the side effects with none of the benefit.

What if the GP cannot help with what I need?

If your problem turns out to be genuinely outside what we can do remotely, the doctor will tell you straight away, point you to the right service, and refund your fee in full. We would rather do that than fill twenty minutes to justify the charge.

What should I do in an emergency?

Call 999 or go to A&E — do not book an online appointment and do not wait for a reply to an email. For urgent problems that are not emergencies, NHS 111 is available 24 hours a day, online or by phone, and can direct you to the right service.

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