Tadalafil

Lasts up to 36 hours, or taken daily so that treatment and the occasion are no longer linked.

Urinary & Sexual Health

Cialis, weekend pill, PDE5 inhibitor

Explained by a GMC-registered GP, not a leaflet

Honest about what we can and cannot prescribe remotely

Side effects given the same weight as benefits

Your NHS records in the room, with your consent

Clinically reviewed by Dr Mohammad Khan · Last reviewed

August 30, 2026

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A 20-minute appointment with a GMC-registered GP for £40. Same-day appointments are usually available, 6am to 10pm, seven days a week.

Private GP care led personally by Dr Mohammad Zubair Khan, GMC 7563469.

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Same-Day Appointments
Sick Notes
Private Prescriptions
Blood Tests
Menopause & HRT
Weight Management
Mental Health
Specialist Referrals
Same-Day Appointments
Sick Notes
Private Prescriptions
Blood Tests
Menopause & HRT
Weight Management
Mental Health
Specialist Referrals

What it is

Tadalafil is a PDE5 inhibitor. It blocks an enzyme that breaks down the signal causing blood vessels in the penis to relax, so blood flow increases in response to arousal.

It does not cause an erection by itself — sexual stimulation is still required. This is the most common misunderstanding, and it accounts for a good number of apparent treatment failures.

Its distinguishing feature is duration. Sildenafil works for around four to six hours; tadalafil for up to 36. That removes the need to plan around a tablet, which many people find matters more than any difference in effectiveness.

What it is used for

  • Erectile dysfunction — as needed, or as a low daily dose
  • Benign prostatic enlargement — urinary symptoms in men, where the daily dose is licensed
  • Both together, which is a common and convenient combination
  • Pulmonary arterial hypertension, at different doses under specialist care

How to take it

Two quite different ways

As needed: 10mg or 20mg, at least 30 minutes before sex. Effective for up to 36 hours, so timing is far less critical than with sildenafil.

Daily: 2.5mg or 5mg every day, at the same time. This separates treatment from the occasion entirely, which many couples strongly prefer, and it also treats prostate symptoms.

Practical points

  • Food does not affect it, unlike sildenafil, which is delayed considerably by a heavy meal
  • Alcohol in moderation is fine; a lot of alcohol impairs erections regardless of the tablet
  • Try it on several separate occasions at an adequate dose before concluding it does not work

Need this reviewed or prescribed?

Book a consultation

Side effects

Common

  • Headache
  • Flushing
  • Indigestion, reflux
  • Blocked nose
  • Back pain and muscle aches — more characteristic of tadalafil than the others, usually mild and settling within a couple of days

Serious — seek help

  • An erection lasting more than four hours (priapism). This is an emergency — go to A&E. Delay risks permanent damage
  • Sudden loss of vision or hearing — stop and seek urgent attention
  • Chest pain during sex — call 999, and tell them you have taken a PDE5 inhibitor, because it changes which treatments are safe

Not suitable if

  • You take nitrates — isosorbide mononitrate, GTN spray. This combination can cause a catastrophic drop in blood pressure and is absolutely contraindicated
  • You take nicorandil
  • You have had a heart attack or stroke in the last 90 days
  • You have unstable angina, or angina during sex
  • You have severe heart failure or very low blood pressure
  • You have had non-arteritic anterior ischaemic optic neuropathy

The nitrate interaction is the one that kills people, and it includes GTN spray used occasionally. Always declare every medicine, including ones you use rarely.

Interactions and monitoring

  • Nitrates and nicorandil — absolutely contraindicated
  • Alpha blockers such as tamsulosin — combined blood pressure drop; started at low dose and separated in timing
  • Ritonavir, ketoconazole, clarithromycin — raise tadalafil levels; lower doses needed
  • Grapefruit juice — raises levels
  • Recreational nitrites ("poppers") — the same dangerous interaction as prescribed nitrates

No routine monitoring of the drug itself. But cardiovascular risk should be assessed — blood pressure, cholesterol, HbA1c and morning testosterone.

Can we prescribe this?

Yes, after a proper assessment. Erectile dysfunction is well suited to remote consultation, because the history does most of the diagnostic work.

What we will not do is treat it as purely a supply problem. Erectile dysfunction is frequently the first sign of cardiovascular disease — appearing on average three to five years before a heart attack or stroke, because the arteries involved are smaller and narrow sooner.

So the consultation covers blood pressure, cholesterol, HbA1c, testosterone, smoking, alcohol, medicines and mood, not just the prescription. We have found significant undiagnosed disease in people who came in only for tablets, and that is the point.

Cost and supply

Tadalafil is available as an inexpensive generic and costs have fallen substantially since patent expiry.

Tadalafil is also sold from pharmacies without a prescription in some circumstances, after a pharmacist consultation.

Branded Cialis costs many times more than generic tadalafil containing the identical drug.

Unlicensed "herbal" erection products bought online frequently contain undeclared PDE5 inhibitors at unknown doses. The MHRA has seized them repeatedly. They are genuinely dangerous with nitrates and in heart disease.

Stopping or switching

Taken as needed, it can simply be stopped. The daily dose can also be stopped without tapering, though prostate symptoms will return.

If it is not working

  1. Confirm it was taken correctly — sexual stimulation is required
  2. Try an adequate dose on several occasions, not once
  3. Consider the daily dose, which suits some men considerably better
  4. Try a different PDE5 inhibitor — response varies between them
  5. Check testosterone, thyroid, glucose and mood, all of which are treatable contributors

Other treatments

Vacuum devices, alprostadil as cream, pellet or injection, and surgical implants for a small number of men.

The reversible causes worth addressing

Some blood pressure tablets, antidepressants and finasteride can all contribute, and alternatives sometimes exist. Smoking, alcohol and weight matter directly. Sudden onset with preserved morning erections points towards anxiety or relationship factors, where psychosexual therapy helps more than any tablet.

Common questions

Tadalafil or sildenafil?

Tadalafil lasts up to 36 hours and is unaffected by food; sildenafil lasts four to six hours and is delayed by a heavy meal. Tadalafil causes back and muscle ache more often. Both are cheap generics, and trying the other is reasonable.

Can I take it with my blood pressure tablets?

Usually yes — except nitrates and nicorandil, which are absolutely contraindicated. Tell us everything you take, including sprays used only occasionally.

Is the daily dose better?

For some men, considerably. It removes the planning entirely and also treats prostate symptoms. It costs more over a month than occasional use.

Why does it give me backache?

A recognised tadalafil effect, usually mild and settling within a day or two. If it persists, a different PDE5 inhibitor may suit better.

Do I need blood tests?

They are worth doing. Erectile dysfunction can be the first sign of cardiovascular disease or diabetes, and finding that early is more valuable than the prescription.

Dr Mohammad Zubair Khan, GMC-registered private GP and founder of Cheshire Clinics

Clinically reviewed by Dr Mohammad Zubair Khan, GMC 7563469

Last reviewed

August 30, 2026

How it works

What happens when you book

£40 for a 20-minute appointment with a GMC-registered GP, 6am to 10pm, seven days a week. Membership is optional and never required.
Cheshire Clinics online GP appointment booking confirmation on mobile
01

Book your appointment

Pick a time that suits you — 6am to 10pm, seven days a week, including weekends and bank holidays. £40 for 20 minutes, self-pay, with no insurance to arrange.
5–10 minutes
Online video consultation with a GMC-registered private GP
02

Meet your GP

A 20-minute video or phone consultation with a GMC-registered GP — long enough for a proper conversation about your symptoms, your history and what matters to you.
20 minutes
Diagnostic testing plan including blood test panel, ECG and urine screening
03

Tests and referrals, if you need them

Where testing will actually answer the question, we arrange it — blood tests and health screening through our laboratory partner, or a referral for ultrasound, X-ray, CT or MRI through private imaging providers. We will also tell you when a scan is not the right next step.
1–7 days
Personalised results and treatment plan from a private GP consultation
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Results and next steps

Your GP talks you through what the results mean and agrees the next step with you. Every consultation ends with your treatment plan in writing, and any prescription goes to your own pharmacy.
20 minutes
GP follow-up reminder for ongoing care and progress monitoring
05

Ongoing care and follow-up

Follow-up appointments, progress monitoring and ongoing advice — including saying plainly when something needs in-person or NHS care instead.

Ongoing

How we compare

Time to be seen

Appointment length

Your NHS record in the room

Written treatment plan

Told when a test isn’t needed

Cost

Varies by practice

Typically 10 minutes

Yes, your full record

Not routinely

Usually

Free

Same day

Often 10 to 15 minutes

Usually not

Sometimes charged

Varies by provider

Often a subscription

Questions about our service

How quickly can I be seen?

Same-day access is usually available, from 6am to 10pm, seven days a week. You choose a time that suits you rather than waiting on hold at 8am.

Will I see the same doctor each time?

Yes. Care is led personally by Dr Mohammad Khan, so you are not passed between clinicians. Continuity is the point of a small practice: someone who knows your history and is listening attentively rather than working through a checklist.

Can you see my NHS records?

Yes, with your consent. We can access your Summary Care Record during the consultation, so your current medications, allergies and significant history are in the room. That means fewer questions you have already answered elsewhere, and safer prescribing.

Are you trying to replace my NHS GP?

No. We are not here to replace GPs, only to support them. Your NHS practice remains responsible for your ongoing care, and with your consent we write to them after the consultation. We are useful when you need to be seen sooner, or want more time than a standard appointment allows.

What is included in the appointment?

Twenty unhurried minutes and a comprehensive assessment. A written treatment plan is included, along with any prescription, sick note or referral letter arising from the consultation, at no extra charge.

How much does it cost?

£40 for 20 minutes, self-pay. Membership is optional and never required. Priced for fairness, because we are not here to charge extortionate amounts for access to a doctor.

What does “treatable online” actually mean?

It means the diagnosis can usually be made from your history and photographs, and that treatment can be arranged safely without examining you. Where a condition is not marked treatable online, it is because examination is the diagnosis — listening to a chest, feeling an abdomen, examining an ear or a joint — or because a procedure or device is needed.

Can you prescribe antibiotics?

Yes, where there is a genuine bacterial infection — cellulitis, impetigo, bacterial urine infections, confirmed strep throat. We will also frequently tell you that you do not need one. Most sore throats, coughs, colds and earaches are viral, and an antibiotic gives you the side effects with none of the benefit.

What if the GP cannot help with what I need?

If your problem turns out to be genuinely outside what we can do remotely, the doctor will tell you straight away, point you to the right service, and refund your fee in full. We would rather do that than fill twenty minutes to justify the charge.

What should I do in an emergency?

Call 999 or go to A&E — do not book an online appointment and do not wait for a reply to an email. For urgent problems that are not emergencies, NHS 111 is available 24 hours a day, online or by phone, and can direct you to the right service.

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