Home

/

Medicines A-Z

/

Folic Acid

Folic Acid

Simple, cheap and genuinely important — with one rule about B12 that must not be skipped.

Vitamins & Deficiency

Vitamin B9, folate supplement

Explained by a GMC-registered GP, not a leaflet

Honest about what we can and cannot prescribe remotely

Side effects given the same weight as benefits

Your NHS records in the room, with your consent

Clinically reviewed by Dr Mohammad Khan · Last reviewed

August 30, 2026

Book a consultation

A 20-minute appointment with a GMC-registered GP for £40. Same-day appointments are usually available, 6am to 10pm, seven days a week.

Private GP care led personally by Dr Mohammad Zubair Khan, GMC 7563469.

Why patients choose Cheshire Clinics

GMC registered doctors badge - every Cheshire Clinics consultation is with a General Medical Council registered GP

GMC-registered

Care led personally by Dr Khan

Royal College of General Practitioners badge - RCGP trained private GP consultations at Cheshire Clinics

RCGP-trained

Attentive, unhurried care that listens properly

Google five star reviews badge - Cheshire Clinics private GP online

Highly rated by patients

Five-star Google reviews from the people we have looked after

Care Quality Commission registered badge - Cheshire Clinics online GP service is registered with the CQC, England's independent regulator of health and social care

CQC-registered

Registered with the Care Quality Commission

Same-Day Appointments
Sick Notes
Private Prescriptions
Blood Tests
Menopause & HRT
Weight Management
Mental Health
Specialist Referrals
Same-Day Appointments
Sick Notes
Private Prescriptions
Blood Tests
Menopause & HRT
Weight Management
Mental Health
Specialist Referrals

What it is

Folic acid is the synthetic form of folate — vitamin B9 — which the body needs to build DNA and to make red blood cells.

Its best-known role is in pregnancy. Taking folic acid before conception and in early pregnancy substantially reduces the risk of neural tube defects such as spina bifida — one of the clearest and most valuable preventive findings in modern medicine.

The timing is what makes it work. The neural tube closes by about week four, frequently before a pregnancy is recognised — so folic acid started when a pregnancy is confirmed has largely missed its window.

What it is used for

  • Before conception and for the first 12 weeks of pregnancy
  • Folate deficiency anaemia
  • Alongside methotrexate, to reduce its side effects
  • In some chronic conditions where folate turnover is high, such as sickle cell disease
  • Where absorption is impaired — coeliac disease, inflammatory bowel disease, after bariatric surgery

How to take it

Pregnancy

  • 400 micrograms daily, from at least one month before conceiving until the end of week 12
  • 5mg daily instead if any of the following apply:
  • Previous pregnancy affected by a neural tube defect
  • You or your partner have a neural tube defect, or a family history
  • Diabetes
  • BMI 30 or above
  • Taking anti-epileptic medication
  • Sickle cell disease or thalassaemia
  • Coeliac disease or another malabsorption condition

That list covers a lot of people, and the higher dose is frequently not offered. It is worth asking.

With methotrexate

Usually 5mg once weekly, on a different day from the methotrexate. Taking them on the same day reduces the methotrexate's effect.

For deficiency

5mg daily for four months, longer where the cause persists.

Need this reviewed or prescribed?

Book a consultation

Side effects

Folic acid is very well tolerated.

  • Nausea, occasionally
  • Loss of appetite, bloating
  • Allergic reaction, rarely

The important risk is not a side effect but a diagnostic one — see below.

Not suitable if

  • You have untreated vitamin B12 deficiency — the crucial exception, explained below
  • You have a folate-dependent cancer, without specialist advice

The B12 rule

Folic acid can correct the anaemia of B12 deficiency while allowing the neurological damage to continue — and that damage can be permanent.

Both deficiencies cause the same type of anaemia, so the blood count improves and everyone is reassured, while nerve damage progresses silently.

This is why B12 must be checked before starting folic acid for anaemia, and treated first if low. It is a genuine and avoidable harm, and it is the single most important point on this page.

Interactions and monitoring

  • Methotrexate — take on different days
  • Anti-epileptic medicines — phenytoin levels can fall; these also increase folate requirements
  • Trimethoprim — a folate antagonist
  • Sulfasalazine reduces folate absorption

Monitoring

Check B12 and folate together, always — never folate alone when investigating anaemia.

Full blood count to confirm the anaemia is responding. Where deficiency is found, the question is why — diet, coeliac disease, alcohol, or malabsorption.

Can we prescribe this?

Yes — though the standard pregnancy dose is available cheaply from any pharmacy, so a prescription is rarely worth paying for.

Where a consultation genuinely helps:

  • Deciding whether you need the higher 5mg dose, which applies to more people than is generally realised
  • Anaemia, where the important step is establishing the cause and checking B12 before starting folic acid
  • Alongside methotrexate, where timing matters

The 5mg dose is not something to self-select, and equally it is frequently not offered to people who should have it.

Cost and supply

400 microgram folic acid is sold in every pharmacy and supermarket for very little, and is included in pregnancy multivitamins.

The 5mg strength requires a prescription and is also inexpensive.

In the UK, folic acid is now added to non-wholemeal wheat flour — a public health measure introduced because so many pregnancies are unplanned that supplementation alone was never going to reach everyone. It does not replace taking a supplement if you are trying to conceive.

Beware pregnancy multivitamins containing vitamin A as retinol, which should be avoided in pregnancy.

Stopping or switching

In pregnancy, stop at the end of week 12 — the neural tube has closed and there is no benefit to continuing, though it does no harm and many people continue a pregnancy multivitamin.

Vitamin D should continue throughout pregnancy and breastfeeding, which is a separate recommendation and often confused with this one.

For deficiency, treatment continues until corrected and the cause addressed.

Where diet is the answer

Leafy green vegetables, pulses, and fortified cereals are good sources — the word folate comes from folium, a leaf. But diet alone cannot reliably deliver enough for pregnancy, which is why the supplement is recommended universally rather than selectively.

Common questions

When should I start it if I am trying to conceive?

At least a month before you conceive. The neural tube closes by about week four, often before you know you are pregnant — which is why starting it when a test is positive largely misses the point.

Do I need 400 micrograms or 5mg?

5mg if you have diabetes, a BMI of 30 or above, take anti-epileptic medication, have coeliac disease, or have a personal or family history of neural tube defects. That is a lot of people, and it is worth asking rather than assuming.

Why must B12 be checked first?

Because folic acid can fix the anaemia of B12 deficiency while nerve damage continues — and that damage can be permanent. Always test both together.

I did not take it and I am already pregnant.

Start now, and do not panic. The greatest benefit is early, but the overall risk remains low and worrying about it changes nothing. Mention it at your first midwife appointment.

Is flour not already fortified?

Yes, in the UK now — but at levels designed to raise the population average, not to replace a supplement. Keep taking it if you are trying to conceive.

Why do I take it weekly with methotrexate?

It reduces methotrexate's side effects — mouth ulcers, nausea, liver upset. Take it on a different day, or it blunts the methotrexate itself.

Dr Mohammad Zubair Khan, GMC-registered private GP and founder of Cheshire Clinics

Clinically reviewed by Dr Mohammad Zubair Khan, GMC 7563469

Last reviewed

August 30, 2026

How it works

What happens when you book

£40 for a 20-minute appointment with a GMC-registered GP, 6am to 10pm, seven days a week. Membership is optional and never required.
Cheshire Clinics online GP appointment booking confirmation on mobile
01

Book your appointment

Pick a time that suits you — 6am to 10pm, seven days a week, including weekends and bank holidays. £40 for 20 minutes, self-pay, with no insurance to arrange.
5–10 minutes
Online video consultation with a GMC-registered private GP
02

Meet your GP

A 20-minute video or phone consultation with a GMC-registered GP — long enough for a proper conversation about your symptoms, your history and what matters to you.
20 minutes
Diagnostic testing plan including blood test panel, ECG and urine screening
03

Tests and referrals, if you need them

Where testing will actually answer the question, we arrange it — blood tests and health screening through our laboratory partner, or a referral for ultrasound, X-ray, CT or MRI through private imaging providers. We will also tell you when a scan is not the right next step.
1–7 days
Personalised results and treatment plan from a private GP consultation
04

Results and next steps

Your GP talks you through what the results mean and agrees the next step with you. Every consultation ends with your treatment plan in writing, and any prescription goes to your own pharmacy.
20 minutes
GP follow-up reminder for ongoing care and progress monitoring
05

Ongoing care and follow-up

Follow-up appointments, progress monitoring and ongoing advice — including saying plainly when something needs in-person or NHS care instead.

Ongoing

How we compare

Time to be seen

Appointment length

Your NHS record in the room

Written treatment plan

Told when a test isn’t needed

Cost

Varies by practice

Typically 10 minutes

Yes, your full record

Not routinely

Usually

Free

Same day

Often 10 to 15 minutes

Usually not

Sometimes charged

Varies by provider

Often a subscription

Questions about our service

How quickly can I be seen?

Same-day access is usually available, from 6am to 10pm, seven days a week. You choose a time that suits you rather than waiting on hold at 8am.

Will I see the same doctor each time?

Yes. Care is led personally by Dr Mohammad Khan, so you are not passed between clinicians. Continuity is the point of a small practice: someone who knows your history and is listening attentively rather than working through a checklist.

Can you see my NHS records?

Yes, with your consent. We can access your Summary Care Record during the consultation, so your current medications, allergies and significant history are in the room. That means fewer questions you have already answered elsewhere, and safer prescribing.

Are you trying to replace my NHS GP?

No. We are not here to replace GPs, only to support them. Your NHS practice remains responsible for your ongoing care, and with your consent we write to them after the consultation. We are useful when you need to be seen sooner, or want more time than a standard appointment allows.

What is included in the appointment?

Twenty unhurried minutes and a comprehensive assessment. A written treatment plan is included, along with any prescription, sick note or referral letter arising from the consultation, at no extra charge.

How much does it cost?

£40 for 20 minutes, self-pay. Membership is optional and never required. Priced for fairness, because we are not here to charge extortionate amounts for access to a doctor.

What does “treatable online” actually mean?

It means the diagnosis can usually be made from your history and photographs, and that treatment can be arranged safely without examining you. Where a condition is not marked treatable online, it is because examination is the diagnosis — listening to a chest, feeling an abdomen, examining an ear or a joint — or because a procedure or device is needed.

Can you prescribe antibiotics?

Yes, where there is a genuine bacterial infection — cellulitis, impetigo, bacterial urine infections, confirmed strep throat. We will also frequently tell you that you do not need one. Most sore throats, coughs, colds and earaches are viral, and an antibiotic gives you the side effects with none of the benefit.

What if the GP cannot help with what I need?

If your problem turns out to be genuinely outside what we can do remotely, the doctor will tell you straight away, point you to the right service, and refund your fee in full. We would rather do that than fill twenty minutes to justify the charge.

What should I do in an emergency?

Call 999 or go to A&E — do not book an online appointment and do not wait for a reply to an email. For urgent problems that are not emergencies, NHS 111 is available 24 hours a day, online or by phone, and can direct you to the right service.

Patient reviews

What our patients say

No reviews published yet.
Ready to see a GP?20 minutes with a GMC-registered doctor. £40, usually same day.
Book a consultation