When should I start it if I am trying to conceive?
At least a month before you conceive. The neural tube closes by about week four, often before you know you are pregnant — which is why starting it when a test is positive largely misses the point.
Do I need 400 micrograms or 5mg?
5mg if you have diabetes, a BMI of 30 or above, take anti-epileptic medication, have coeliac disease, or have a personal or family history of neural tube defects. That is a lot of people, and it is worth asking rather than assuming.
Why must B12 be checked first?
Because folic acid can fix the anaemia of B12 deficiency while nerve damage continues — and that damage can be permanent. Always test both together.
I did not take it and I am already pregnant.
Start now, and do not panic. The greatest benefit is early, but the overall risk remains low and worrying about it changes nothing. Mention it at your first midwife appointment.
Is flour not already fortified?
Yes, in the UK now — but at levels designed to raise the population average, not to replace a supplement. Keep taking it if you are trying to conceive.
Why do I take it weekly with methotrexate?
It reduces methotrexate's side effects — mouth ulcers, nausea, liver upset. Take it on a different day, or it blunts the methotrexate itself.