Is it really not just willpower?
Correct. Weight is regulated by hormonal systems that respond to weight loss by increasing hunger and lowering the calories you burn at rest — and that response persists for years. This is measured physiology, not an excuse. It is precisely why treatments acting on appetite regulation succeed where advice repeatedly failed.
Will I regain the weight if I stop the injections?
Most likely, yes — trial evidence suggests around two thirds of the loss returns within a year of stopping. This is the same biology that causes regain after any diet. It is the strongest argument for regarding these as long-term treatments rather than a course, and for factoring the ongoing cost into the decision before you start.
Is my BMI reliable?
Only roughly. It cannot distinguish muscle from fat, and it under-estimates risk in people of South Asian, Chinese, Black African and Caribbean family origin, for whom lower thresholds apply. Waist-to-height ratio is more useful — aim to keep your waist under half your height.
Could a medical problem be causing it?
Sometimes, and it is worth checking. Thyroid disease, PCOS and — rarely — Cushing's syndrome all contribute. Far more often the answer is a medication: several antipsychotics, antidepressants, diabetes drugs and steroids cause significant weight gain, and alternatives sometimes exist.
Which diet is best?
The one you can maintain. Head-to-head trials of low carb, low fat, Mediterranean and intermittent fasting show broadly similar results — adherence, not composition, predicts the outcome. Anyone insisting there is a single correct diet is overstating the evidence.
Do I have to lose a lot for it to be worth it?
No, and this is the most encouraging fact here. Five to ten per cent produces meaningful improvements in blood pressure, blood sugar, cholesterol, sleep apnoea and joint pain. You do not need to reach an ideal weight to gain most of the health benefit.
Why does exercise not seem to shift the scales?
Because exercise burns fewer calories than most people assume and appetite partly compensates. It is far more effective at maintaining a loss than producing one — and it improves blood pressure, blood sugar, mood and cardiovascular risk whether or not your weight changes. It is worth doing for those reasons alone.
Can I get weight-loss injections if my BMI is normal?
No. These are licensed for a BMI of 30 or above, or 27.5 or above with a weight-related condition, with lower thresholds for some ethnic groups. Prescribing them for cosmetic weight loss at a healthy weight is not clinically appropriate and we will decline — whatever other providers may offer.