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Montelukast

Montelukast

A useful add-on tablet for asthma and hay fever — carrying a mood and behaviour warning that everyone taking it should know.

Respiratory

Singulair, leukotriene receptor antagonist

Explained by a GMC-registered GP, not a leaflet

Honest about what we can and cannot prescribe remotely

Side effects given the same weight as benefits

Your NHS records in the room, with your consent

Clinically reviewed by Dr Mohammad Khan · Last reviewed

August 30, 2026

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A 20-minute appointment with a GMC-registered GP for £40. Same-day appointments are usually available, 6am to 10pm, seven days a week.

Private GP care led personally by Dr Mohammad Zubair Khan, GMC 7563469.

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Same-Day Appointments
Sick Notes
Private Prescriptions
Blood Tests
Menopause & HRT
Weight Management
Mental Health
Specialist Referrals
Same-Day Appointments
Sick Notes
Private Prescriptions
Blood Tests
Menopause & HRT
Weight Management
Mental Health
Specialist Referrals

What it is

Montelukast blocks leukotrienes — inflammatory chemicals released in allergic reactions that narrow airways, increase mucus and cause swelling.

It is a tablet rather than an inhaler, which is its practical appeal, and it acts on a different pathway from inhaled steroids — so the two work together rather than duplicating each other.

It is an add-on, not a substitute for a preventer inhaler.

What it is used for

  • Asthma, added to inhaled steroid treatment where control is inadequate
  • Exercise-induced asthma, where it is particularly useful
  • Allergic rhinitis alongside asthma — treating both with one tablet
  • Asthma in young children, where inhaler technique is difficult

It is especially useful where asthma and hay fever coexist, which is a very common combination.

How to take it

  • Adults: 10mg once daily, in the evening
  • Children have lower doses, as chewable tablets or granules
  • Take it at the same time each day
  • For exercise-induced symptoms, it is taken regularly rather than before exercise

Evening dosing reflects the overnight and early-morning worsening typical of asthma.

Allow two to four weeks to judge whether it is helping. If there is no clear benefit by then, it is usually stopped rather than continued indefinitely — which is a genuinely important point, as many people stay on it for years without anyone asking whether it ever worked.

Need this reviewed or prescribed?

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Side effects

Common

  • Headache
  • Abdominal pain
  • Thirst, and upper respiratory infections

The important one

The MHRA has issued specific warnings about neuropsychiatric reactions to montelukast. These are uncommon but real, can begin at any point during treatment, and are frequently not connected to the tablet:

  • Sleep disturbance, nightmares and vivid dreams
  • Anxiety, agitation, irritability, low mood
  • Behaviour changes in children — aggression, hyperactivity, difficulty concentrating
  • Depression, and rarely suicidal thoughts

Anyone taking montelukast, and any parent giving it to a child, should know about this before starting. If these symptoms appear, stop the tablet and seek advice — they generally resolve on stopping.

Not suitable if

  • You have had a reaction to it before
  • You have had neuropsychiatric symptoms on it previously

Existing depression, anxiety or behavioural difficulties are not absolute barriers, but they change the balance and should be discussed openly before starting.

It is generally considered acceptable in pregnancy where needed for asthma control, since uncontrolled asthma carries greater risk.

Interactions and monitoring

  • Phenobarbital and rifampicin — reduce montelukast levels

Drug interactions are few. No blood monitoring is needed.

What should be monitored

Mood, sleep and behaviour — at every review, and asked about directly rather than waited for. In children, ask the child and the parent separately where possible.

Also review whether it is still helping. Montelukast continued for years without benefit is common and worth stopping.

Can we prescribe this?

Yes, for continuing established treatment, and for allergic rhinitis where inhaled and intranasal treatment has not been enough.

Before starting it we will always discuss the neuropsychiatric warning, and we will ask directly about existing mental health difficulties, because that changes the balance for some people.

As with any asthma medicine, we do not diagnose asthma remotely and we do not manage poorly controlled asthma at a distance. Montelukast is an add-on to inhaled treatment, never a replacement for it.

Cost and supply

Montelukast is an inexpensive generic, available as standard tablets, chewable tablets and granules for young children.

A private prescription typically costs little more than the England NHS prescription charge.

Stopping or switching

It can be stopped without tapering.

Stop and seek advice if

  • Mood changes, nightmares, agitation or unusual behaviour develop — in yourself or your child
  • Any thoughts of self-harm

These usually resolve within days to weeks of stopping.

If it is not helping

Stop it after four weeks rather than continuing indefinitely. Not everyone responds, and there is no benefit to staying on a medicine that has not helped.

Alternatives

  • Increasing the inhaled steroid dose
  • A combination inhaler with a long-acting bronchodilator
  • A steroid nasal spray and antihistamine, where allergic rhinitis is driving symptoms
  • Specialist referral for biologic treatment in severe asthma

Common questions

Is the mental health warning serious?

Yes, and it deserves to be taken seriously rather than glossed over. The reactions are uncommon, but they are real, they can start at any time, and they are frequently attributed to something else. Knowing about them in advance is what allows them to be recognised.

My child has become aggressive since starting it.

Stop it and seek advice. Behaviour change in children is a recognised effect and usually settles on stopping. This is not something to wait out.

Can it replace my inhaler?

No. It is an add-on to inhaled steroid treatment, never a substitute. Stopping a preventer because you are on montelukast is dangerous.

How long before it works?

Two to four weeks. If there is no clear benefit by then, it should generally be stopped.

Why in the evening?

Because asthma characteristically worsens overnight and in the early morning, and evening dosing matches that pattern.

Dr Mohammad Zubair Khan, GMC-registered private GP and founder of Cheshire Clinics

Clinically reviewed by Dr Mohammad Zubair Khan, GMC 7563469

Last reviewed

August 30, 2026

How it works

What happens when you book

£40 for a 20-minute appointment with a GMC-registered GP, 6am to 10pm, seven days a week. Membership is optional and never required.
Cheshire Clinics online GP appointment booking confirmation on mobile
01

Book your appointment

Pick a time that suits you — 6am to 10pm, seven days a week, including weekends and bank holidays. £40 for 20 minutes, self-pay, with no insurance to arrange.
5–10 minutes
Online video consultation with a GMC-registered private GP
02

Meet your GP

A 20-minute video or phone consultation with a GMC-registered GP — long enough for a proper conversation about your symptoms, your history and what matters to you.
20 minutes
Diagnostic testing plan including blood test panel, ECG and urine screening
03

Tests and referrals, if you need them

Where testing will actually answer the question, we arrange it — blood tests and health screening through our laboratory partner, or a referral for ultrasound, X-ray, CT or MRI through private imaging providers. We will also tell you when a scan is not the right next step.
1–7 days
Personalised results and treatment plan from a private GP consultation
04

Results and next steps

Your GP talks you through what the results mean and agrees the next step with you. Every consultation ends with your treatment plan in writing, and any prescription goes to your own pharmacy.
20 minutes
GP follow-up reminder for ongoing care and progress monitoring
05

Ongoing care and follow-up

Follow-up appointments, progress monitoring and ongoing advice — including saying plainly when something needs in-person or NHS care instead.

Ongoing

How we compare

Time to be seen

Appointment length

Your NHS record in the room

Written treatment plan

Told when a test isn’t needed

Cost

Varies by practice

Typically 10 minutes

Yes, your full record

Not routinely

Usually

Free

Same day

Often 10 to 15 minutes

Usually not

Sometimes charged

Varies by provider

Often a subscription

Questions about our service

How quickly can I be seen?

Same-day access is usually available, from 6am to 10pm, seven days a week. You choose a time that suits you rather than waiting on hold at 8am.

Will I see the same doctor each time?

Yes. Care is led personally by Dr Mohammad Khan, so you are not passed between clinicians. Continuity is the point of a small practice: someone who knows your history and is listening attentively rather than working through a checklist.

Can you see my NHS records?

Yes, with your consent. We can access your Summary Care Record during the consultation, so your current medications, allergies and significant history are in the room. That means fewer questions you have already answered elsewhere, and safer prescribing.

Are you trying to replace my NHS GP?

No. We are not here to replace GPs, only to support them. Your NHS practice remains responsible for your ongoing care, and with your consent we write to them after the consultation. We are useful when you need to be seen sooner, or want more time than a standard appointment allows.

What is included in the appointment?

Twenty unhurried minutes and a comprehensive assessment. A written treatment plan is included, along with any prescription, sick note or referral letter arising from the consultation, at no extra charge.

How much does it cost?

£40 for 20 minutes, self-pay. Membership is optional and never required. Priced for fairness, because we are not here to charge extortionate amounts for access to a doctor.

What does “treatable online” actually mean?

It means the diagnosis can usually be made from your history and photographs, and that treatment can be arranged safely without examining you. Where a condition is not marked treatable online, it is because examination is the diagnosis — listening to a chest, feeling an abdomen, examining an ear or a joint — or because a procedure or device is needed.

Can you prescribe antibiotics?

Yes, where there is a genuine bacterial infection — cellulitis, impetigo, bacterial urine infections, confirmed strep throat. We will also frequently tell you that you do not need one. Most sore throats, coughs, colds and earaches are viral, and an antibiotic gives you the side effects with none of the benefit.

What if the GP cannot help with what I need?

If your problem turns out to be genuinely outside what we can do remotely, the doctor will tell you straight away, point you to the right service, and refund your fee in full. We would rather do that than fill twenty minutes to justify the charge.

What should I do in an emergency?

Call 999 or go to A&E — do not book an online appointment and do not wait for a reply to an email. For urgent problems that are not emergencies, NHS 111 is available 24 hours a day, online or by phone, and can direct you to the right service.

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