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Loratadine

Loratadine

The antihistamine with the most reassuring pregnancy data, and a sensible once-daily default.

Allergy

Clarityn, non-drowsy allergy tablet

Explained by a GMC-registered GP, not a leaflet

Honest about what we can and cannot prescribe remotely

Side effects given the same weight as benefits

Your NHS records in the room, with your consent

Clinically reviewed by Dr Mohammad Khan · Last reviewed

August 30, 2026

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A 20-minute appointment with a GMC-registered GP for £40. Same-day appointments are usually available, 6am to 10pm, seven days a week.

Private GP care led personally by Dr Mohammad Zubair Khan, GMC 7563469.

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Same-Day Appointments
Sick Notes
Private Prescriptions
Blood Tests
Menopause & HRT
Weight Management
Mental Health
Specialist Referrals

What it is

Loratadine is a second-generation antihistamine, blocking H1 receptors to prevent the effects of histamine.

It is long-acting, so a single daily dose covers 24 hours, and it penetrates the brain far less than older antihistamines — which is what makes it non-drowsy for most people.

It has the largest accumulated safety data in pregnancy of any antihistamine, which is why it tends to be the first recommendation there.

What it is used for

  • Hay fever and allergic rhinitis
  • Hives and allergic skin reactions
  • Itching from insect bites and allergic reactions
  • Pet, dust and mould allergy

How to take it

  • Adults and children over 12: 10mg once daily
  • Can be taken with or without food
  • Children aged 2 to 12 are dosed by weight, using the syrup

Start before the season

Begin two weeks before your usual season and take it every day. Antihistamines prevent symptoms far more effectively than they relieve established ones.

Once daily is genuinely once daily — a second tablet later in the day is not the answer to breakthrough symptoms, and a nasal spray is.

Need this reviewed or prescribed?

Book a consultation

Side effects

Very well tolerated.

  • Headache
  • Drowsiness — uncommon, though slightly more than fexofenadine
  • Dry mouth, tiredness
  • Increased appetite, occasionally

In children, hyperactivity is occasionally reported rather than sedation.

Not suitable if

  • You have had a reaction to loratadine before
  • You have severe liver disease — the dose may need reducing

Loratadine is generally considered a first-choice antihistamine in pregnancy and is compatible with breastfeeding.

Interactions and monitoring

Interactions are few and rarely of practical importance.

  • Erythromycin, ketoconazole and cimetidine raise levels, generally without consequence
  • Alcohol — minimal additive effect, unlike with older antihistamines

No monitoring required.

Hives with fever, joint pain, weight loss or bruising should be investigated rather than simply treated.

Can we prescribe this?

Loratadine is inexpensive and available everywhere, so a prescription is rarely worth paying for.

What is worth a consultation:

  • Hay fever not responding to it — which usually means the nasal spray is missing or misused rather than the tablet failing
  • Hives lasting more than six weeks, which needs a proper plan
  • Allergy in pregnancy, where the choice of drug genuinely matters
  • Suspected food or drug allergy, where the important question is what to avoid and whether adrenaline is needed — not which tablet to take

Cost and supply

One of the cheapest medicines in any pharmacy. Own-brand loratadine costs a fraction of the branded version and is chemically identical.

Available as tablets and syrup, both over the counter.

For a whole hay fever season, buying in bulk is considerably cheaper than small packets — and daily use through the season is how it is meant to be taken.

Stopping or switching

Stop at any time; no tapering needed.

If it is not enough

  1. Add a steroid nasal spray — more effective than any antihistamine for blocked nose. Start early, use daily, allow two weeks
  2. Add antihistamine eye drops
  3. Try saline nasal rinses
  4. Switch antihistamine — individual response varies, and cetirizine or fexofenadine may suit you better
  5. Consider immunotherapy for severe unresponsive rhinitis

What not to do

Do not switch to a sedating antihistamine such as chlorphenamine in the hope that stronger sedation means stronger treatment. It does not, and next-day impairment is a real cost.

Common questions

Loratadine or cetirizine?

Cetirizine is marginally more effective for some people; loratadine is marginally less likely to cause drowsiness. Both are reasonable, and trying the other is sensible if one disappoints.

Is it safe in pregnancy?

It has the most reassuring pregnancy data of the antihistamines, and is usually the first choice. Still worth mentioning to whoever is caring for you.

Can I give it to my child?

Yes, from age 2 as syrup, dosed by weight. Follow the packaging carefully.

Why is it not working for my blocked nose?

Because antihistamines are weak for congestion. A steroid nasal spray is the treatment for that, and it is the missing piece in most disappointing hay fever treatment.

Can I drink alcohol?

Loratadine does not add meaningfully to alcohol's sedative effect, unlike older antihistamines.

Dr Mohammad Zubair Khan, GMC-registered private GP and founder of Cheshire Clinics

Clinically reviewed by Dr Mohammad Zubair Khan, GMC 7563469

Last reviewed

August 30, 2026

How it works

What happens when you book

£40 for a 20-minute appointment with a GMC-registered GP, 6am to 10pm, seven days a week. Membership is optional and never required.
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Pick a time that suits you — 6am to 10pm, seven days a week, including weekends and bank holidays. £40 for 20 minutes, self-pay, with no insurance to arrange.
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A 20-minute video or phone consultation with a GMC-registered GP — long enough for a proper conversation about your symptoms, your history and what matters to you.
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Diagnostic testing plan including blood test panel, ECG and urine screening
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Tests and referrals, if you need them

Where testing will actually answer the question, we arrange it — blood tests and health screening through our laboratory partner, or a referral for ultrasound, X-ray, CT or MRI through private imaging providers. We will also tell you when a scan is not the right next step.
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Your GP talks you through what the results mean and agrees the next step with you. Every consultation ends with your treatment plan in writing, and any prescription goes to your own pharmacy.
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Ongoing care and follow-up

Follow-up appointments, progress monitoring and ongoing advice — including saying plainly when something needs in-person or NHS care instead.

Ongoing

How we compare

Time to be seen

Appointment length

Your NHS record in the room

Written treatment plan

Told when a test isn’t needed

Cost

Varies by practice

Typically 10 minutes

Yes, your full record

Not routinely

Usually

Free

Same day

Often 10 to 15 minutes

Usually not

Sometimes charged

Varies by provider

Often a subscription

Questions about our service

How quickly can I be seen?

Same-day access is usually available, from 6am to 10pm, seven days a week. You choose a time that suits you rather than waiting on hold at 8am.

Will I see the same doctor each time?

Yes. Care is led personally by Dr Mohammad Khan, so you are not passed between clinicians. Continuity is the point of a small practice: someone who knows your history and is listening attentively rather than working through a checklist.

Can you see my NHS records?

Yes, with your consent. We can access your Summary Care Record during the consultation, so your current medications, allergies and significant history are in the room. That means fewer questions you have already answered elsewhere, and safer prescribing.

Are you trying to replace my NHS GP?

No. We are not here to replace GPs, only to support them. Your NHS practice remains responsible for your ongoing care, and with your consent we write to them after the consultation. We are useful when you need to be seen sooner, or want more time than a standard appointment allows.

What is included in the appointment?

Twenty unhurried minutes and a comprehensive assessment. A written treatment plan is included, along with any prescription, sick note or referral letter arising from the consultation, at no extra charge.

How much does it cost?

£40 for 20 minutes, self-pay. Membership is optional and never required. Priced for fairness, because we are not here to charge extortionate amounts for access to a doctor.

What does “treatable online” actually mean?

It means the diagnosis can usually be made from your history and photographs, and that treatment can be arranged safely without examining you. Where a condition is not marked treatable online, it is because examination is the diagnosis — listening to a chest, feeling an abdomen, examining an ear or a joint — or because a procedure or device is needed.

Can you prescribe antibiotics?

Yes, where there is a genuine bacterial infection — cellulitis, impetigo, bacterial urine infections, confirmed strep throat. We will also frequently tell you that you do not need one. Most sore throats, coughs, colds and earaches are viral, and an antibiotic gives you the side effects with none of the benefit.

What if the GP cannot help with what I need?

If your problem turns out to be genuinely outside what we can do remotely, the doctor will tell you straight away, point you to the right service, and refund your fee in full. We would rather do that than fill twenty minutes to justify the charge.

What should I do in an emergency?

Call 999 or go to A&E — do not book an online appointment and do not wait for a reply to an email. For urgent problems that are not emergencies, NHS 111 is available 24 hours a day, online or by phone, and can direct you to the right service.

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