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Fluconazole

Fluconazole

One capsule treats most thrush. Recurrent thrush needs a different conversation entirely.

Infection

Diflucan, Canesten Oral, antifungal capsule

Explained by a GMC-registered GP, not a leaflet

Honest about what we can and cannot prescribe remotely

Side effects given the same weight as benefits

Your NHS records in the room, with your consent

Clinically reviewed by Dr Mohammad Khan · Last reviewed

August 30, 2026

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A 20-minute appointment with a GMC-registered GP for £40. Same-day appointments are usually available, 6am to 10pm, seven days a week.

Private GP care led personally by Dr Mohammad Zubair Khan, GMC 7563469.

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Same-Day Appointments
Sick Notes
Private Prescriptions
Blood Tests
Menopause & HRT
Weight Management
Mental Health
Specialist Referrals
Same-Day Appointments
Sick Notes
Private Prescriptions
Blood Tests
Menopause & HRT
Weight Management
Mental Health
Specialist Referrals

What it is

Fluconazole is a triazole antifungal. It blocks an enzyme fungi need to build their cell membranes, so the membrane fails and the fungus cannot survive.

Its great advantage over creams and pessaries is that it is absorbed and distributed throughout the body, so a single capsule treats the infection from the inside rather than requiring several nights of local treatment.

What it is used for

  • Vaginal thrush — a single 150mg capsule
  • Recurrent vaginal thrush — an induction course followed by weekly suppression for six months
  • Oral thrush, and thrush affecting the penis
  • Fungal skin and nail infections, at longer durations
  • Serious systemic fungal infection, in hospital

How to take it

  • Vaginal thrush: one 150mg capsule, taken once, with or without food
  • Symptoms usually improve within one to three days; itching may take a little longer
  • Recurrent thrush: an initial three doses 72 hours apart, then one weekly for six months

A second dose can be taken after three days for severe symptoms — but if two doses have not worked, the diagnosis needs revisiting rather than a third.

Adding a topical antifungal cream to the external skin helps with soreness that the capsule alone does not settle quickly.

Need this reviewed or prescribed?

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Side effects

Common

  • Nausea, stomach discomfort
  • Headache
  • Diarrhoea

A single dose is usually very well tolerated. Side effects become more relevant with prolonged courses.

Less common

  • Rash — and rarely, severe skin reactions
  • Liver upset with prolonged use
  • Effects on heart rhythm at higher doses or with interacting medicines

Not suitable if

  • You are pregnant — oral fluconazole is avoided; clotrimazole pessaries and cream are used instead
  • You take medicines that prolong the QT interval
  • You have significant liver disease
  • You have had a reaction to an azole antifungal

In pregnancy, topical treatment is the right answer and works perfectly well — it simply takes a few nights rather than one capsule.

Interactions and monitoring

Even a single dose inhibits liver enzymes, so a few interactions matter despite the short exposure.

  • Warfarin — the INR can rise; monitoring advised
  • Statins — raised levels and muscle risk with repeated dosing
  • Some antihistamines, antipsychotics and antiarrhythmics — QT prolongation
  • Phenytoin, ciclosporin, tacrolimus — raised levels

No monitoring for a single dose. Six-month suppressive courses prompt periodic liver function checks.

Recurrent thrush should prompt an HbA1c — undiagnosed diabetes presents this way more often than people expect.

Can we prescribe this?

Yes — though for a single episode of thrush, a pharmacy is quicker and cheaper than a consultation with us. We would rather tell you that than take the fee.

Where a consultation earns its place is recurrent thrush — four or more episodes in a year. That is a different problem, needs a longer suppressive course, and should prompt a check for undiagnosed diabetes.

It also matters because several conditions are mistaken for thrush — bacterial vaginosis, eczema of the vulval skin, lichen sclerosus and, occasionally, something needing examination. Repeatedly self-treating for thrush that is not thrush delays those diagnoses.

Cost and supply

A single fluconazole capsule is available over the counter from any pharmacy, and costs a few pounds. That is almost always the fastest and cheapest route for a first episode, and we will say so rather than charge for a consultation.

Branded versions cost several times more than generic ones and contain exactly the same drug.

Six-month suppressive courses require a prescription, and remain inexpensive.

Stopping or switching

A single dose is complete in itself. Suppressive courses should be finished, as stopping early frequently leads to recurrence.

When to reconsider the diagnosis

If two doses have not worked, it is probably not thrush. Consider:

  • Bacterial vaginosis — fishy odour, thin grey discharge, little itching
  • Vulval eczema or dermatitis — often from soaps, wipes or the antifungal cream itself
  • Lichen sclerosus — needs examination and specific treatment, and is frequently mistaken for thrush for years
  • A resistant Candida species, which needs a swab to identify

Alternatives

  • Clotrimazole pessary and cream — equally effective, and the choice in pregnancy
  • Itraconazole — for resistant infection

Common questions

Should I see you or go to a pharmacy?

For a first, typical episode, go to the pharmacy — it is quicker and cheaper. Come to us for recurrent thrush, for symptoms that have not responded, or where you are not sure it is thrush at all.

How quickly does it work?

Improvement within one to three days. External soreness can take longer, and a cream applied to the skin helps with that.

Is it thrush or something else?

Thrush: thick white discharge, itching, soreness. Bacterial vaginosis: thin grey discharge, fishy smell, little itching. If treatment is not working, the label is the first thing to question.

Can I take it in pregnancy?

No — use clotrimazole pessaries and cream instead. They are effective and safe.

I keep getting thrush. Why?

Four or more episodes a year warrants a proper look. Undiagnosed diabetes, recent antibiotics, and irritation from soaps and washes are common contributors. An HbA1c is worth doing. A six-month suppressive course usually breaks the cycle.

Does my partner need treating?

Only if they have symptoms. Thrush is not a sexually transmitted infection, and routine partner treatment is not needed.

Dr Mohammad Zubair Khan, GMC-registered private GP and founder of Cheshire Clinics

Clinically reviewed by Dr Mohammad Zubair Khan, GMC 7563469

Last reviewed

August 30, 2026

How it works

What happens when you book

£40 for a 20-minute appointment with a GMC-registered GP, 6am to 10pm, seven days a week. Membership is optional and never required.
Cheshire Clinics online GP appointment booking confirmation on mobile
01

Book your appointment

Pick a time that suits you — 6am to 10pm, seven days a week, including weekends and bank holidays. £40 for 20 minutes, self-pay, with no insurance to arrange.
5–10 minutes
Online video consultation with a GMC-registered private GP
02

Meet your GP

A 20-minute video or phone consultation with a GMC-registered GP — long enough for a proper conversation about your symptoms, your history and what matters to you.
20 minutes
Diagnostic testing plan including blood test panel, ECG and urine screening
03

Tests and referrals, if you need them

Where testing will actually answer the question, we arrange it — blood tests and health screening through our laboratory partner, or a referral for ultrasound, X-ray, CT or MRI through private imaging providers. We will also tell you when a scan is not the right next step.
1–7 days
Personalised results and treatment plan from a private GP consultation
04

Results and next steps

Your GP talks you through what the results mean and agrees the next step with you. Every consultation ends with your treatment plan in writing, and any prescription goes to your own pharmacy.
20 minutes
GP follow-up reminder for ongoing care and progress monitoring
05

Ongoing care and follow-up

Follow-up appointments, progress monitoring and ongoing advice — including saying plainly when something needs in-person or NHS care instead.

Ongoing

How we compare

Time to be seen

Appointment length

Your NHS record in the room

Written treatment plan

Told when a test isn’t needed

Cost

Varies by practice

Typically 10 minutes

Yes, your full record

Not routinely

Usually

Free

Same day

Often 10 to 15 minutes

Usually not

Sometimes charged

Varies by provider

Often a subscription

Questions about our service

How quickly can I be seen?

Same-day access is usually available, from 6am to 10pm, seven days a week. You choose a time that suits you rather than waiting on hold at 8am.

Will I see the same doctor each time?

Yes. Care is led personally by Dr Mohammad Khan, so you are not passed between clinicians. Continuity is the point of a small practice: someone who knows your history and is listening attentively rather than working through a checklist.

Can you see my NHS records?

Yes, with your consent. We can access your Summary Care Record during the consultation, so your current medications, allergies and significant history are in the room. That means fewer questions you have already answered elsewhere, and safer prescribing.

Are you trying to replace my NHS GP?

No. We are not here to replace GPs, only to support them. Your NHS practice remains responsible for your ongoing care, and with your consent we write to them after the consultation. We are useful when you need to be seen sooner, or want more time than a standard appointment allows.

What is included in the appointment?

Twenty unhurried minutes and a comprehensive assessment. A written treatment plan is included, along with any prescription, sick note or referral letter arising from the consultation, at no extra charge.

How much does it cost?

£40 for 20 minutes, self-pay. Membership is optional and never required. Priced for fairness, because we are not here to charge extortionate amounts for access to a doctor.

What does “treatable online” actually mean?

It means the diagnosis can usually be made from your history and photographs, and that treatment can be arranged safely without examining you. Where a condition is not marked treatable online, it is because examination is the diagnosis — listening to a chest, feeling an abdomen, examining an ear or a joint — or because a procedure or device is needed.

Can you prescribe antibiotics?

Yes, where there is a genuine bacterial infection — cellulitis, impetigo, bacterial urine infections, confirmed strep throat. We will also frequently tell you that you do not need one. Most sore throats, coughs, colds and earaches are viral, and an antibiotic gives you the side effects with none of the benefit.

What if the GP cannot help with what I need?

If your problem turns out to be genuinely outside what we can do remotely, the doctor will tell you straight away, point you to the right service, and refund your fee in full. We would rather do that than fill twenty minutes to justify the charge.

What should I do in an emergency?

Call 999 or go to A&E — do not book an online appointment and do not wait for a reply to an email. For urgent problems that are not emergencies, NHS 111 is available 24 hours a day, online or by phone, and can direct you to the right service.

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