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Otomize Ear Spray

Otomize Ear Spray

The standard spray for outer ear infection — and the one most often used with the wrong technique.

Eye & Ear

Dexamethasone, neomycin and acetic acid spray

Explained by a GMC-registered GP, not a leaflet

Honest about what we can and cannot prescribe remotely

Side effects given the same weight as benefits

Your NHS records in the room, with your consent

Clinically reviewed by Dr Mohammad Khan · Last reviewed

September 5, 2026

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Specialist Referrals

What it is

Otomize is a combination spray for the outer ear canal, containing three things that each do a different job:

  • Dexamethasone, a steroid, which reduces the swelling that makes the canal narrow and painful
  • Neomycin, an antibiotic, which treats the bacteria
  • Acetic acid, which restores the canal's natural acidity — bacteria and fungi both dislike an acidic ear

The steroid is doing more of the work than most people assume. Much of the pain of otitis externa comes from a swollen canal under pressure, and reducing that swelling is what produces relief within a day or two.

What it is used for

  • Otitis externa — infection or inflammation of the outer ear canal, sometimes called swimmer's ear
  • Eczema of the ear canal with secondary infection

It is not for middle ear infection. Otitis media sits behind an intact eardrum, and a spray in the canal cannot reach it.

How to take it

The technique, which matters more than the prescription

  1. One spray into the affected ear, three times a day, for up to seven days
  2. Pull the ear gently up and back before spraying — this straightens the canal so the spray reaches down it rather than sitting at the entrance
  3. Do not push the nozzle deep into the ear. At the opening is correct
  4. Stay still for a minute or two afterwards so it does not run straight out
  5. Warm the bottle in your hand first — cold spray into the ear canal causes dizziness

Length of course

Seven days, and not routinely longer. Prolonged use of an aminoglycoside like neomycin in the ear is avoided, and extended steroid use can encourage fungal overgrowth — which then looks like treatment failure and gets treated with more of the same.

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Side effects

  • Stinging or burning on application — common, and the acetic acid is usually responsible
  • Local irritation or itching
  • Allergic contact dermatitis to neomycin — more common than people realise. Worth suspecting when an ear gets itchier and more inflamed on treatment rather than better
  • Fungal overgrowth with prolonged use — intensely itchy, often with a damp discharge

The one to take seriously

Neomycin can damage hearing and balance if it reaches the middle or inner ear. That is why a perforated eardrum matters, and why courses are kept short.

Not suitable if

  • You have, or might have, a perforated eardrum — this is the important one. Neomycin reaching the middle ear can cause permanent hearing damage
  • You have grommets in place
  • You are allergic to neomycin or other aminoglycosides
  • The ear problem is viral — herpes zoster of the ear, for example

How to suspect a perforation: a sudden discharge of fluid or pus with relief of pain, a history of a burst eardrum, or long-standing hearing loss on that side. If there is any real doubt, the ear needs looking at before this is used.

Avoided in pregnancy unless clearly necessary.

Interactions and monitoring

No significant systemic drug interactions — very little is absorbed from a correctly used ear spray.

No monitoring is required for a standard seven-day course.

What should be reviewed is whether it worked. An ear that is no better after seven days needs re-examining rather than a repeat prescription — the likeliest explanations are a fungal infection, a neomycin allergy, or a canal too swollen for the spray to penetrate, and each needs something different.

Can we prescribe this?

Yes, where the picture is a straightforward outer ear infection and there is no reason to suspect a perforated eardrum. A careful history covers most of that: previous perforations, grommets, sudden discharge with pain relief, or known hearing loss on that side.

The honest limitation is that we cannot look in your ear. That matters more here than for most remote prescribing, because the single contraindication that causes lasting harm — a perforation — is one only an otoscope can exclude with certainty. Where the history raises any doubt, we will ask you to be examined rather than prescribe.

What needs seeing in person: severe pain with swelling spreading onto the face or neck, fever, a canal so swollen it has closed, hearing loss, facial weakness, or anyone with diabetes or a suppressed immune system and a severe ear infection — necrotising otitis externa is a serious diagnosis and is not something to manage over video.

This page is information, not an offer to supply.

Cost and supply

Otomize is prescription-only and relatively expensive for what it is — more than the England NHS prescription charge on a private script. NHS prescriptions are free in Wales.

The cheaper things worth knowing about

  • Acetic acid ear spray (EarCalm) is available over the counter without any prescription, costs a few pounds, and is genuinely effective for mild otitis externa. For an early, mild case this is a reasonable first step and we would say so before charging you for a consultation
  • Keeping the ear dry costs nothing and does more than people expect

Where paying is justified

A painful, swollen, discharging ear that has not settled with over-the-counter acetic acid, or one where the pain is significant enough that the steroid component is what you actually need.

Stopping or switching

Stop after seven days. This is not a treatment to continue until symptoms fully resolve — short courses are deliberate.

If it has not worked

Do not simply repeat it. Three things explain most failures, and each needs a different answer:

  • Fungal otitis externa — intensely itchy, often follows antibiotic drops, needs an antifungal instead
  • Neomycin allergy — the ear became more inflamed on treatment. Needs a neomycin-free alternative
  • A canal too swollen for the spray to get down — needs microsuction and sometimes an ear wick, which is an in-person procedure

Alternatives

  • Acetic acid spray — over the counter, mild cases
  • Ciprofloxacin drops — safe with a perforated eardrum, which Otomize is not
  • Clotrimazole solution — for fungal infection
  • Flumetasone with clioquinol — an alternative combination

Common questions

How quickly should it work?

Pain usually improves within 24 to 48 hours, largely because of the steroid reducing the swelling. Full resolution takes the week.

No improvement at all after 48 hours is worth reporting rather than waiting out the course.

Why does it sting?

The acetic acid. It is unpleasant but expected, and it settles after the first couple of doses. Warming the bottle in your hand first helps, and prevents the dizziness that cold spray in the ear can cause.

Can I use it if my eardrum is perforated?

No — this is the one that matters. Neomycin reaching the middle ear can damage hearing permanently. If you have ever had a burst eardrum, have grommets, or had a sudden discharge that relieved severe pain, say so before using it.

Can I go swimming?

Not during treatment, and keep the ear dry. Water is what caused it in a great many cases. A shower cap or a smear of petroleum jelly on cotton wool keeps water out while washing.

Why has it come back?

Usually because the ear keeps getting wet, or because cotton buds are still being used. Cotton buds strip the protective wax and scratch the canal, which is precisely how infection gets in. Nothing smaller than your elbow goes in your ear — the advice is old and it is correct.

My ear is itchier than before. Is that normal?

No, and it is worth acting on. Increasing itch on treatment suggests either a neomycin allergy or a fungal overgrowth, and both need a different medicine rather than more of this one.

Dr Mohammad Zubair Khan, GMC-registered private GP and founder of Cheshire Clinics

Clinically reviewed by Dr Mohammad Zubair Khan, GMC 7563469

Last reviewed

September 5, 2026

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Same-day access is usually available, from 6am to 10pm, seven days a week. You choose a time that suits you rather than waiting on hold at 8am.

Will I see the same doctor each time?

Yes. Care is led personally by Dr Mohammad Khan, so you are not passed between clinicians. Continuity is the point of a small practice: someone who knows your history and is listening attentively rather than working through a checklist.

Can you see my NHS records?

Yes, with your consent. We can access your Summary Care Record during the consultation, so your current medications, allergies and significant history are in the room. That means fewer questions you have already answered elsewhere, and safer prescribing.

Are you trying to replace my NHS GP?

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What if the GP cannot help with what I need?

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What should I do in an emergency?

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